CAS No. 2226167-02-6
Batch:
Purity:99.81
Chemical Structure
Check the
Befotertinib mesylate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-[1-(2,2,2-trifluoroethyl)indol-3-yl]pyrimidin-2-yl]amino]phenyl]prop-2-enamide;methanesulfonic acid | |
|---|---|---|
| CAS Number | 2226167-02-6 | |
| Molecular Formula |
C29H32F3N7O2.CH4O3S |
|
| Molecular Weight (MW) | 663.71 | |
| InChIKey | FFQDXZLQXPZZDJ-UHFFFAOYSA-N |
Befotertinib mesylate (D-mesylate) is an orally active, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It selectively targets EGFR resistance mutations, including T790M, to block downstream oncogenic receptor signaling pathways. Inhibition of mutant EGFR leads to suppression of tumor cell survival and proliferation in non-small cell lung cancer models harboring primary EGFR mutations or secondary T790M resistance. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(150.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 5 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.