CAS No. 2607829-38-7
Batch:
Purity:99.02
Chemical Structure
Check the
BDTX-1535
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (E)-N-[4-(3-chloro-2-fluoroanilino)-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-1-yl]ethynyl]quinazolin-6-yl]-4-morpholin-4-ylbut-2-enamide | |
|---|---|---|
| CAS Number | 2607829-38-7 | |
| Molecular Formula |
C30H30ClFN6O2 |
|
| Molecular Weight (MW) | 561.05 | |
| InChIKey | LMOVDLRMIRLIJF-TUVXKDNKSA-N |
Biological Activity
BDTX-1535 is an orally active, highly selective, and irreversible epidermal growth factor receptor (EGFR) inhibitor targeting both classical and uncommon oncogenic EGFR mutations, including resistance variants like C797S and extracellular domain mutants such as EGFRvIII. By selectively binding to mutant EGFR active dimers while sparing wild-type EGFR, it suppresses downstream EGFR signaling pathways, leading to inhibited cell proliferation and suppressed tumor growth in non-small cell lung cancer and glioblastoma models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(178.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.