CAS No. 20448-79-7
Batch:
Purity:97
Chemical Structure
Check the
BCH
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid | |
|---|---|---|
| CAS Number | 20448-79-7 | |
| Molecular Formula |
C8H13NO2 |
|
| Molecular Weight (MW) | 155.19 | |
| SMILES | NC1(CC2CCC1C2)C(O)=O | |
| InChIKey | MPUVBVXDFRDIPT-UHFFFAOYSA-N |
BCH is a selective and competitive inhibitor of system L amino acid transporter 1 (LAT1). By blocking the LAT1-mediated uptake of essential neutral amino acids, BCH starves cells of crucial nutrients required for protein synthesis. This inhibition disrupts intracellular amino acid homeostasis and downstream nutrient sensing, suppressing tumor cell growth and effectively inducing apoptosis in various cancer cells. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 31 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 31 mg/mL |
| DMSO |
1 mg/mL
(6.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.