CAS No. 2781215-95-8

Batch: Purity:99.71
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BCFTP Chemical Structure
Chemical Structure
Check the BCFTP product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2781215-95-8
Molecular Formula

C23H17ClF4N2O2S
Molecular Weight (MW) 496.91

Biological Activity

BCFTP is a potent and orally active selective positive allosteric modulator (PAM) of human Mas-related G-protein coupled receptor X1 (MrgprX1). By potentiating endogenous agonist signaling through MrgprX1, BCFTP selectively suppresses spinal C-fibre nociceptive signal transmission. This mechanistic action downstream of receptor activation effectively alleviates heat hyperalgesia and spontaneous neuropathic pain without inducing pruritogenic responses or analgesic tolerance. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 49.5 mg/mL (99.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 25 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Solinski HJ, et al. Pharmacol Rev. 2014;66(3):570-97.

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Note: Technical data last updated: Sep 1, 2026.