CAS No. 695207-56-8
Batch:
Purity:99.30
Chemical Structure
Check the
BC-LI-0186
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide | |
|---|---|---|
| CAS Number | 695207-56-8 | |
| Molecular Formula |
C22H27N3O4S |
|
| Molecular Weight (MW) | 429.53 | |
| SMILES | CC(C)C1=C(C)N(C)N(C1=O)C2=CC=C(C=C2)[S](=O)(=O)NCCOC3=CC=CC=C3 | |
| InChIKey | SQYWMHPZMHDCHP-UHFFFAOYSA-N |
BC-LI-0186 is a selective blocker of the interaction between leucyl-tRNA synthetase (LRS) and Ras-related GTP-binding protein D (RagD) (IC= that binds to LRS with a Kd of. By competing against RagD for LRS binding, it inhibits lysosomal localization of LRS and downstream mTORC1 pathway activity, thereby suppressing the growth of rapamycin-resistant cancer cells and cancer-associated mTOR mutants. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(200.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.