CAS No. 2871056-82-3
Batch:
Purity:
Chemical Structure
Check the
CHK1-IN-12
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-[[5-[2-(3-aminocyclobutyl)oxy-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrile | |
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| CAS Number | 2871056-82-3 | |
| Molecular Formula |
C19H19N7O2 |
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| Molecular Weight (MW) | 377.40 | |
| InChIKey | ZUNOPUCDGHVJOF-UHFFFAOYSA-N |
Biological Activity
BBI-355 is an orally bioavailable, potent, and selective small-molecule inhibitor of checkpoint kinase 1 (CHK1). By disrupting CHK1 signaling in the DNA damage response pathway, it impairs replication stress management and abrogates cell cycle checkpoints in cancer cells with extrachromosomal DNA (ecDNA) oncogene amplifications. Consequently, BBI-355 induces DNA damage accumulation, suppresses tumor growth, and exhibits marked antitumor activity both as a monotherapy and combined with targeted agents. [1]
How to Prepare Stock Solution?
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Concentration
Volume
Mass
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Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
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Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.