CAS No. 1402608-02-9
Batch:
Purity:99.89
Chemical Structure
Check the
BAY1125976
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[4-(1-aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide | |
|---|---|---|
| CAS Number | 1402608-02-9 | |
| Molecular Formula |
C23H21N5O
|
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| Molecular Weight (MW) | 383.45 | |
| SMILES | C1CC(C1)(C2=CC=C(C=C2)C3=C(N4C(=N3)C=CC(=N4)C(=O)N)C5=CC=CC=C5)N | |
| InChIKey | JBGYKRAZYDNCNV-UHFFFAOYSA-N |
BAY1125976 is a selective allosteric AKT inhibitor that targets AKT1 (IC50 =atATP), AKT2 (IC50 =atATP), and AKT3 (IC50 =atATP). By blocking AKT kinase activation, it suppresses downstream AKT/mTOR signaling pathways, leading to reduced tumor cell proliferation and potent inhibition of AKT-dependent tumor growth in vivo. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
11 mg/mL
(28.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
11 mg/mL
(28.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.