CAS No. 2409479-29-2
Batch:
Purity:99.95
Chemical Structure
Check the
BAY-985
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[4-[(1R)-1-[2-[[6-[6-(dimethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl]amino]-4-pyridinyl]ethyl]piperazin-1-yl]-3,3,3-trifluoropropan-1-one | |
|---|---|---|
| CAS Number | 2409479-29-2 | |
| Molecular Formula |
C27H30F3N9O |
|
| Molecular Weight (MW) | 553.58 | |
| SMILES | CC(C1=CC(=NC=C1)NC2=NC3=C(N2)C=C(C=C3)C4=CC(=NC=N4)N(C)C)N5CCN(CC5)C(=O)CC(F)(F)F | |
| InChIKey | HZRJHVDNTDBTOZ-QGZVFWFLSA-N |
BAY-985 is a potent and selective dual inhibitor of TBK1 (IC50 = 2 nM) and IKKε (IC50 = 2 nM). It effectively blocks downstream signaling by inhibiting the phosphorylation of IRF3 (IC50 =, a key transactivator in innate immune and oncogenic signaling cascades. Through this target engagement, BAY-985 exerts antiproliferative effects in SK-MEL-2 melanoma cells (IC50 =. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(180.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(180.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.