CAS No. 1799753-84-6
Batch:
Purity:99.07
Chemical Structure
Check the
BAY-876
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-N-[1-[(4-cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide | |
|---|---|---|
| CAS Number | 1799753-84-6 | |
| Molecular Formula |
C24H16F4N6O2 |
|
| Molecular Weight (MW) | 496.42 | |
| SMILES | CC1=C(C(=NN1CC2=CC=C(C=C2)C#N)C(F)(F)F)NC(=O)C3=CC(=NC4=C3C=CC(=C4)F)C(=O)N | |
| InChIKey | BKLJDIJJOOQUFG-UHFFFAOYSA-N |
Biological Activity
BAY-876 is a potent and selective GLUT1 inhibitor (IC50 of exhibiting a selectivity factor of >100 against GLUT2, GLUT3, and GLUT4. By blocking GLUT1-mediated glucose transport, BAY-876 impairs glycolysis and disrupts cellular energy metabolism in glycolytically dependent cancer cells. This targeted metabolic inhibition suppresses cell proliferation and attenuates tumor growth by starving cells of essential metabolic intermediates. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
99 mg/mL
(199.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
99 mg/mL
(199.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.