CAS No. 724440-27-1
Batch:
Purity:99.19
Chemical Structure
Check the
BAY-8002
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[[5-(benzenesulfonyl)-2-chlorobenzoyl]amino]benzoic acid | |
|---|---|---|
| CAS Number | 724440-27-1 | |
| Molecular Formula |
C20H14ClNO5S |
|
| Molecular Weight (MW) | 415.85 | |
| SMILES | C1=CC=C(C=C1)S(=O)(=O)C2=CC(=C(C=C2)Cl)C(=O)NC3=CC=CC=C3C(=O)O | |
| InChIKey | CLAUJSRBKSRTGQ-UHFFFAOYSA-N |
BAY-8002 is a novel monocarboxylate transporter 1 (MCT1) inhibitor that potently suppresses bidirectional lactate transport across cellular membranes. By inhibiting MCT1-mediated solute transport, the compound disrupts cancer cell metabolic homeostasis and impedes transmembrane nutrient exchange. Consequently, target blockade significantly increases intratumor lactate levels and transiently modulates pyruvate levels, altering metabolic flux within the tumor microenvironment. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(199.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 28 mg/mL |
| Water | Insoluble |
| DMSO |
83 mg/mL
(199.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 21 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.