CAS No. 2413020-56-9
Batch:
Purity:99.80
Chemical Structure
Check the
BAY-593
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2R)-3,3,3-trifluoro-2-methoxy-1-[(11R)-11-(2-methoxyphenyl)-3,9-diazaspiro[5.5]undecan-3-yl]-2-phenylpropan-1-one | |
|---|---|---|
| CAS Number | 2413020-56-9 | |
| Molecular Formula |
C26H31F3N2O3 |
|
| Molecular Weight (MW) | 476.53 | |
| InChIKey | CUNCJCWHVHIRLT-SQJMNOBHSA-N |
Biological Activity
BAY-593 is a small molecule inhibitor and in vivo chemical probe targeting geranylgeranyltransferase-I (GGTase-I). By inhibiting GGTase-I, it blocks the activation of upstream Rho-GTPases, leading to downstream inactivation of oncogenic YAP1/TAZ signaling pathways. Consequently, BAY-593 suppresses YAP1/TAZ-driven transcriptional gene expression, resulting in significant inhibition of cancer cell proliferation in vitro and potent anti-tumor activity in vivo. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
95 mg/mL
(199.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 95 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.