CAS No. 1699717-32-2
Batch:
Purity:97.26
Chemical Structure
Check the
BAY-545
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-ethyl-6-(4-hydroxypiperidine-1-carbonyl)-5-methyl-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4-dione | |
|---|---|---|
| CAS Number | 1699717-32-2 | |
| Molecular Formula |
C18H22F3N3O4S |
|
| Molecular Weight (MW) | 433.45 | |
| SMILES | CCN1C(=O)C2=C(N(C1=O)CCC(F)(F)F)SC(=C2C)C(=O)N3CCC(CC3)O | |
| InChIKey | NTYVAKNEYLJAPT-UHFFFAOYSA-N |
BAY-545 is a potent adenosine A2B receptor antagonist that selectively targets A2B adenosine receptor signaling. Blockade of the A2B receptor inhibits intracellular cyclic AMP (cAMP) accumulation and downstream protein kinase A signaling pathways. This inhibition modulates inflammatory responses, vascular reactivity, and cellular proliferation across diverse pathophysiological models. Consequently, BAY-545 serves as a useful pharmacological tool for elucidating adenosine receptor-dependent signaling mechanisms. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(200.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 87 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.