CAS No. 2080306-23-4
Batch:
Purity:96.02
Chemical Structure
Check the
BAY-299
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-(3-hydroxypropyl)-2-(1,3,6-trimethyl-2-oxobenzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione | |
|---|---|---|
| CAS Number | 2080306-23-4 | |
| Molecular Formula |
C25H23N3O4 |
|
| Molecular Weight (MW) | 429.47 | |
| InChIKey | OFWWWKWUCDUISA-UHFFFAOYSA-N |
BAY-299 is a potent dual bromodomain inhibitor targeting BRPF2 (bromodomain and PHD finger 2) as well as TAF1 and TAF1L (TATA box binding protein-associated factors 1 and 1L). By selectively blocking the bromodomains of BRPF2 and TAF1/TAF1L, BAY-299 disrupts chromatin recognition and acetylated lysine binding within transcription factor complexes. This inhibition suppresses downstream gene expression, impairs chromatin remodeling, and inhibits cellular proliferation in epigenetic research models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(200.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.