CAS No. 2732902-08-6
Batch:
Purity:99.92
Chemical Structure
Check the
BAY 2965501
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R)-2-(N-[4-amino-5-(4-methoxybenzoyl)-1,3-thiazol-2-yl]-4-fluoroanilino)propanamide | |
|---|---|---|
| CAS Number | 2732902-08-6 | |
| Molecular Formula |
C20H19FN4O3S |
|
| Molecular Weight (MW) | 414.46 | |
| InChIKey | HSBUVKDEUUJREZ-LLVKDONJSA-N |
BAYis a potent, selective inhibitor of diacylglycerol kinase zeta (DGKζ). By blocking DGKζ activity, it restores cellular diacylglycerol levels in anergic T-cells and induces downstream ERK phosphorylation within the RAS/ERK pathway. These molecular events reactivate T-cell effector functions, overcome adenosine- and prostaglandin E2-mediated immunosuppression in the tumor microenvironment, and enhance T-cell-mediated tumor cell killing. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
83 mg/mL
(200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.