CAS No. 2244904-70-7
Batch:
Purity:98.25
Chemical Structure
Check the
BAY-293
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6,7-dimethoxy-2-methyl-N-[(1R)-1-[4-[2-(methylaminomethyl)phenyl]thiophen-2-yl]ethyl]quinazolin-4-amine | |
|---|---|---|
| CAS Number | 2244904-70-7 | |
| Molecular Formula |
C25H28N4O2S |
|
| Molecular Weight (MW) | 448.58 | |
| SMILES | CC1=NC2=CC(=C(C=C2C(=N1)NC(C)C3=CC(=CS3)C4=CC=CC=C4CNC)OC)OC | |
| InChIKey | WEGLOYDTDILXDA-OAHLLOKOSA-N |
BAY-293 is a selective inhibitor of the KRAS-SOS1 interaction with an IC50 of 21 nM. By binding to SOS1, it prevents SOS1-mediated guanine nucleotide exchange on KRAS, thereby blocking the formation of active GTP-bound KRAS. Consequently, BAY-293 suppresses downstream RAS signaling through the MAPK/ERK pathway and inhibits cell proliferation in KRAS-dependent cancer models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(200.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 90 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.