CAS No. 2242464-44-2

Batch: Purity:99.80
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BAY 2416964 Chemical Structure
Chemical Structure
Check the BAY 2416964 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(1-methylpyrazol-4-yl)-3-oxopyridazine-4-carboxamide
CAS Number 2242464-44-2
Molecular Formula

C18H18ClN5O3
Molecular Weight (MW) 387.82
SMILES CC(CO)NC(=O)C1=CC(=NN(C1=O)C2=CN(N=C2)C)C3=CC=C(C=C3)Cl
InChIKey YAGSZKAJPHGVOV-NSHDSACASA-N

Biological Activity

BAY 2416964 is a potent, orally active antagonist of the aryl hydrocarbon receptor (AhR) with an IC50 of. By inhibiting AhR-mediated transcriptional signaling, this agent disrupts downstream immunosuppressive cascades and tumor cell survival pathways. AhR activation driven by tryptophan metabolites promotes immune evasion and tumor growth, making its targeted inhibition a promising strategy for the treatment of solid tumors. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (201.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 1.5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Opitz CA, et al. Nature. 2011;478(7368):197-203.

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Note: Technical data last updated: Sep 1, 2026.