CAS No. 1891087-61-8
Batch:
Purity:99.43
Chemical Structure
Check the
BAY-1816032
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[3,5-difluoro-4-[[3-[5-methoxy-4-[(3-methoxy-4-pyridinyl)amino]pyrimidin-2-yl]indazol-1-yl]methyl]phenoxy]ethanol | |
|---|---|---|
| CAS Number | 1891087-61-8 | |
| Molecular Formula |
C27H24F2N6O4 |
|
| Molecular Weight (MW) | 534.51 | |
| SMILES | COC1=CN=C(N=C1NC2=C(C=NC=C2)OC)C3=NN(C4=CC=CC=C43)CC5=C(C=C(C=C5F)OCCO)F | |
| InChIKey | QVOGVAVHOLLLAZ-UHFFFAOYSA-N |
BAY-1816032 is an orally available inhibitor of budding uninhibited by benzimidazoles 1 (BUB1) kinase. By inhibiting BUB1, it disrupts the spindle assembly checkpoint, impairing chromosome alignment and mitotic progression. This interference deregulates mitotic signaling and induces chromosome segregation errors, leading to the inhibition of tumor cell proliferation and demonstrating preclinical antitumor activity in various cancer models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(93.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.