CAS No. 2639638-66-5
Batch:
Purity:96.61
Chemical Structure
Check the
BAY-069
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[4-chloro-3-(2-methylphenoxy)naphthalen-1-yl]-6-(trifluoromethyl)-1H-pyrimidine-2,4-dione | |
|---|---|---|
| CAS Number | 2639638-66-5 | |
| Molecular Formula |
C22H14ClF3N2O3 |
|
| Molecular Weight (MW) | 446.81 | |
| InChIKey | UNSHMXUHOHBLIQ-UHFFFAOYSA-N |
BAY-069 is a potent dual inhibitor of branched-chain amino acid transaminase 1 (BCAT1, IC50 = 31 nM) and BCAT2 (IC50 = 153 nM). By suppressing BCAT1/2-mediated transamination, the compound blocks the catabolism of essential branched-chain amino acids into keto acids and glutamate. This selective metabolic inhibition increases intracellular branched-chain amino acid accumulation in tumor cells and disrupts cancer-associated metabolic pathways without causing non-specific cytotoxicity.
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
89 mg/mL
(199.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 89 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.