CAS No. 861875-60-7

Batch: Purity:99.24
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BAW2881 (NVP-BAW2881) Chemical Structure
Chemical Structure
Check the BAW2881 (NVP-BAW2881) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-(2-aminopyrimidin-4-yl)oxy-N-[3-(trifluoromethyl)phenyl]naphthalene-1-carboxamide
CAS Number 861875-60-7
Molecular Formula

C22H15F3N4O2
Molecular Weight (MW) 424.38
SMILES C1=CC(=CC(=C1)NC(=O)C2=CC=CC3=C2C=CC(=C3)OC4=NC(=NC=C4)N)C(F)(F)F
InChIKey MLLQJNIKDWEEFT-UHFFFAOYSA-N

Biological Activity

BAW2881 (NVP-BAW2881) is a synthetic receptor tyrosine kinase inhibitor targeting vascular endothelial growth factor receptors VEGFR1, VEGFR2, and VEGFR3, as well as PDGFRβ, c-Kit, and RET. By blocking VEGFR-mediated signaling, it suppresses endothelial cell activation and downstream angiogenic pathway activity. This inhibition results in reduced vascular permeability, decreased capillary formation, and attenuation of localized tissue inflammation.[1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 84 mg/mL (197.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 20 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Shibuya M. BMB Rep. 2013;46(10):496-504.

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Note: Technical data last updated: Sep 1, 2026.