CAS No. 743461-65-6

Batch: Purity:99.09
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Batefenterol  Chemical Structure
Chemical Structure
Check the Batefenterol  product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 743461-65-6
Molecular Formula

C40H42ClN5O7
Molecular Weight (MW) 740.24
SMILES COC1=CC(=C(C=C1CNCC(C2=C3C=CC(=O)NC3=C(C=C2)O)O)Cl)NC(=O)CCN4CCC(CC4)OC(=O)NC5=CC=CC=C5C6=CC=CC=C6

Biological Activity

Batefenterol (GSK961081) is a dual-acting muscarinic receptor antagonist and β2-adrenoceptor agonist, exhibiting high affinity for human M2 muscarinic receptors (Ki 1.4 nM), M3 muscarinic receptors (Ki 1.3 nM), and β2-adrenoceptors (Ki 3.7 nM). By simultaneously inhibiting M3 receptor-mediated bronchoconstriction and stimulating β2-adrenoceptor-driven intracellular cAMP accumulation, it promotes robust and sustained relaxation of airway smooth muscle cells.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (135.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.