CAS No. 802906-73-6
Batch:
Purity:98.09
Chemical Structure
Check the
Basimglurant
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-chloro-4-[2-[1-(4-fluorophenyl)-2,5-dimethylimidazol-4-yl]ethynyl]pyridine | |
|---|---|---|
| CAS Number | 802906-73-6 | |
| Molecular Formula |
C18H13ClFN3 |
|
| Molecular Weight (MW) | 325.77 | |
| InChIKey | UPZWINBEAHDTLA-UHFFFAOYSA-N |
Basimglurant is a potent and selective negative allosteric modulator of metabotropic glutamate receptor 5 (mGlu5) with a Kd of. By allosterically inhibiting mGlu5 receptor activity, it suppresses downstream intracellular calcium signaling and attenuates glutamatergic neurotransmission. This targeted inhibition regulates activity-dependent synaptic plasticity, dampens neuronal hyperexcitability, and modulates central nervous system pathway signaling. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(199.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 21 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.