CAS No. 1187595-84-1

Batch: Purity:99.99
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Baricitinib phosphate Chemical Structure
Chemical Structure
Check the Baricitinib phosphate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1187595-84-1
Molecular Formula

C16H20N7O6PS
Molecular Weight (MW) 469.41
SMILES CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O

Ordering Information

Biological Activity

Baricitinib phosphate is a selective inhibitor of JAK1 (IC50 5.9 nM) and JAK2 (IC50 5.7 nM), displaying ~70-fold selectivity over JAK3 and ~10-fold selectivity over Tyk2 without inhibiting c-Met or Chk2. By blocking JAK-STAT signaling pathways, it suppresses cytokine-driven intracellular signaling, downstream gene expression, and inflammatory mediator release, while also inhibiting viral entry into target host cells. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 94 mg/mL (200.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.