CAS No. 1187594-09-7

Batch: Purity:99.96
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Baricitinib (LY3009104) Chemical Structure
Chemical Structure
Check the Baricitinib (LY3009104) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile
CAS Number 1187594-09-7
Molecular Formula

C16H17N7O2S
Molecular Weight (MW) 371.42
SMILES CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
InChIKey XUZMWHLSFXCVMG-UHFFFAOYSA-N

Ordering Information

Biological Activity

Baricitinib (LY3009104) is a selective inhibitor of JAK1 (IC50 5.9 nM) and JAK2 (IC50 5.7 nM), displaying selectivity over JAK3 and Tyk2. By blocking intracellular JAK/STAT signaling pathways, it suppresses cytokine-mediated gene expression and downstream inflammatory responses. Additionally, baricitinib disrupts receptor-mediated endocytosis to impair viral entry into target cells, demonstrating therapeutic activity against autoimmune disorders and inflammatory conditions. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 74 mg/mL (199.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.