CAS No. 218600-44-3

Batch: Purity:98.45
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Bardoxolone (CDDO) Chemical Structure
Chemical Structure
Check the Bardoxolone (CDDO) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylic acid
CAS Number 218600-44-3
Molecular Formula

C31H41NO4
Molecular Weight (MW) 491.66
SMILES CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)O)C
InChIKey TXGZJQLMVSIZEI-UQMAOPSPSA-N

Ordering Information

Biological Activity

Bardoxolone (CDDO) is a synthetic oleanane triterpenoid and potent activator of Nrf2 that acts by releasing Nrf2 from KEAP1. Dissociation from KEAP1 allows Nrf2 to translocate to the nucleus, driving downstream cytoprotective and antioxidant gene expression while inhibiting NF-kB inflammatory pathways. Through these mechanisms, Bardoxolone suppresses cell proliferation and induces programmed cell death (apoptosis) in cancer cell lines.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 6 mg/mL (12.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.