CAS No. 356568-70-2
Batch:
Purity:98.96
Chemical Structure
Check the
Barbadin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-amino-5-(4-benzylphenyl)thieno[2,3-d]pyrimidin-4-one | |
|---|---|---|
| CAS Number | 356568-70-2 | |
| Molecular Formula |
C19H15N3OS |
|
| Molecular Weight (MW) | 333.41 | |
| SMILES | O=C1C(C(C2=CC=C(CC3=CC=CC=C3)C=C2)=CS4)=C4N=CN1N | |
| InChIKey | OCBXPCSXEQQADU-UHFFFAOYSA-N |
Barbadin is a selective β-arrestin/β2-adaptin interaction inhibitor, targeting β-arrestin 1 (IC50 19.1 μM) and β-arrestin 2 (IC50 15.6 μM). It selectively blocks agonist-induced endocytosis of β2-adrenergic, V2-vasopressin, and angiotensin II type-1 receptors without interfering with receptor-arrestin complex formation. Downstream, Barbadin blunts ERK1/2 signaling pathways and exhibits pro-apoptotic activity while inducing G0/G1 cell cycle arrest in agonist-stimulated cancer cells. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(200.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.