CAS No. 73630-08-7

Batch: Purity:99.03
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BAPTA tetrapotassium salt Chemical Structure
Chemical Structure
Check the BAPTA tetrapotassium salt product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 73630-08-7
Molecular Formula

C22H24N2O10.4K
Molecular Weight (MW) 632.83
SMILES [K+].[K+].[K+].[K+].[O-]C(=O)CN(CC([O-])=O)C1=C(OCCOC2=C(C=CC=C2)N(CC([O-])=O)CC([O-])=O)C=CC=C1

Biological Activity

BAPTA tetrapotassium salt is a non-permeable, selective calcium chelator with over 105-fold greater affinity for Ca2+ than Mg2+ and a dissociation constant of 1.1 × 10−7 M for Ca2+. By rapidly chelating extracellular calcium ions, it blocks extracellular calcium influx and perturbs intracellular calcium signaling pathways, inhibiting calcium-dependent cellular responses and physiological processes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 100 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Tsien RY. Biochemistry. 1980;19(11):2396-404.

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Note: Technical data last updated: Sep 1, 2026.