CAS No. 1985605-59-1
Batch:
Purity:99.01
Chemical Structure
Check the
Baloxavir
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3R)-2-[(11S)-7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl]-11-hydroxy-5-oxa-1,2,8-triazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-9,12-dione | |
|---|---|---|
| CAS Number | 1985605-59-1 | |
| Molecular Formula |
C24H19F2N3O4S |
|
| Molecular Weight (MW) | 483.49 | |
| SMILES | OC1=C2N(C=CC1=O)N(C3COCCN3C2=O)C4C5=C(CSC6=CC=CC=C46)C(=C(F)C=C5)F | |
| InChIKey | FIDLLEYNNRGVFR-CTNGQTDRSA-N |
Baloxavir is a first-in-class, potent cap-dependent endonuclease inhibitor that targets the PA subunit of the influenza virus polymerase complex. By selectively inhibiting cap-dependent endonuclease activity, baloxavir blocks viral RNA transcription and suppresses influenza viral replication in infected cells. This targeted inhibition disrupts the essential cap-snatching process, preventing viral mRNA synthesis and downstream replication across various influenza virus strains. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
25 mg/mL
(51.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
48 mg/mL
(99.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.