CAS No. 354813-19-7
Batch:
Purity:98.06
Chemical Structure
Check the
Balicatib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide | |
|---|---|---|
| CAS Number | 354813-19-7 | |
| Molecular Formula |
C23H33N5O2 |
|
| Molecular Weight (MW) | 411.54 | |
| SMILES | CCCN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3(CCCCC3)C(=O)NCC#N | |
| InChIKey | LLCRBOWRJOUJAE-UHFFFAOYSA-N |
Balicatib (AAE-581) is a potent and selective inhibitor of cathepsin K, a key lysosomal cysteine protease involved in bone metabolism. By targeting cathepsin K, balicatib disrupts osteoclastic collagen degradation and bone matrix remodeling. This targeted inhibition impairs osteoclast-mediated bone resorption pathways, suppressing extracellular matrix cleavage and preventing excess bone turnover without disrupting overall cellular differentiation processes. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
82 mg/mL
(199.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.