CAS No. 2842012-69-3
Batch:
Purity:99.34
Chemical Structure
Check the
BAL-0028
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-ethoxy-4-(3-fluorophenyl)-N-(1H-indazol-7-ylmethyl)-N-methylbenzamide | |
|---|---|---|
| CAS Number | 2842012-69-3 | |
| Molecular Formula |
C24H22FN3O2 |
|
| Molecular Weight (MW) | 403.45 | |
| InChIKey | VTZLXMQBXAOBJF-UHFFFAOYSA-N |
BAL-0028 is an indazole-class inhibitor of NLRP3 activation (IC50 = 25 nM) that binds to the NACHT domain of NLRP3 with Kd values ranging from 104 to 123 nM. Blockade of the NLRP3 inflammasome pathway suppresses caspase-1-dependent maturation and secretion of pro-inflammatory cytokines, including IL-1β and IL-18. This downstream functional suppression prevents gasdermin D-mediated pyroptosis and exerts broad anti-inflammatory phenotypes.
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Concentration
Volume
Mass
|
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
81 mg/mL
(200.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.