CAS No. 19906-72-0
Batch:
Purity:99
Chemical Structure
Check the
Bakkenolide A
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R,3aR,7S,7aR)-7,7a-dimethyl-4'-methylidenespiro[3,3a,4,5,6,7-hexahydro-1H-indene-2,3'-oxolane]-2'-one | |
|---|---|---|
| CAS Number | 19906-72-0 | |
| Molecular Formula |
C15H22O2 |
|
| Molecular Weight (MW) | 234.33 | |
| SMILES | CC1CCCC2C1(CC3(C2)C(=C)COC3=O)C | |
| InChIKey | OVXAYHNZXBOVPV-QMGNLALYSA-N |
Bakkenolide A is a natural sesquiterpene lactone that functions as an anti-inflammatory and antineoplastic agent. It modulates key pro-inflammatory signaling pathways, primarily suppressing NF-kB activation and downstream inflammatory cytokine production. Through these signaling interactions, sesquiterpene lactones inhibit cell proliferation and promote apoptosis across cancer cell lines, displaying selective cytotoxicity and immunomodulatory activity. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
47 mg/mL
(200.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.