CAS No. 19906-72-0

Bakkenolide A Chemical Structure
Chemical Structure
Check the Bakkenolide A product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R,3aR,7S,7aR)-7,7a-dimethyl-4'-methylidenespiro[3,3a,4,5,6,7-hexahydro-1H-indene-2,3'-oxolane]-2'-one
CAS Number 19906-72-0
Molecular Formula

C15H22O2
Molecular Weight (MW) 234.33
SMILES CC1CCCC2C1(CC3(C2)C(=C)COC3=O)C
InChIKey OVXAYHNZXBOVPV-QMGNLALYSA-N

Biological Activity

Bakkenolide A is a natural sesquiterpene lactone that functions as an anti-inflammatory and antineoplastic agent. It modulates key pro-inflammatory signaling pathways, primarily suppressing NF-kB activation and downstream inflammatory cytokine production. Through these signaling interactions, sesquiterpene lactones inhibit cell proliferation and promote apoptosis across cancer cell lines, displaying selective cytotoxicity and immunomodulatory activity. [1][2]

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Solubility

Reference

[1] Bork PM, et al. FEBS Lett. 1997;402(1):85-90.

[2] Ghantous A, et al. Drug Discov Today. 2010;15(15-16):668-78.

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Note: Technical data last updated: Sep 1, 2026.