CAS No. 1202764-53-1
Batch:
Purity:99.77
Chemical Structure
Check the
B022
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[1-(2-amino-5-chloropyrimidin-4-yl)-2,3-dihydroindol-6-yl]-2-(1,3-thiazol-2-yl)but-3-yn-2-ol | |
|---|---|---|
| CAS Number | 1202764-53-1 | |
| Molecular Formula |
C19H16ClN5OS |
|
| Molecular Weight (MW) | 397.88 | |
| InChIKey | OKFYOOFXVBCIIP-UHFFFAOYSA-N |
B022 is a potent and selective small-molecule inhibitor targeting NF-κB-inducing kinase (NIK). By suppressing NIK signaling, B022 effectively blocks NIK-dependent p100-to-p52 processing and downregulates the expression of pro-inflammatory genes both in vitro and in vivo. Consequently, inhibition of this noncanonical NF-κB pathway attenuates hepatic oxidative stress and protects liver tissue against toxin-induced inflammation and severe acute liver injury. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
80 mg/mL
(201.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.