Azodicarbonamide

Catalog No.S2430 Synonyms: ADA, HPH-116, NSC 674447

For research use only.

Azodicarbonamide is the first known nucleocapsid inhibitor that inhibits HIV-1 and a broad range of retroviruses by targeting the nucleocapsid CCHC domains. Azodicarbonamide inhibits the HIV-1RF-induced cytopathicity of CEM-SS cells with an EC50 of 38 µM in a standard cell-based antiviral assay .

Azodicarbonamide Chemical Structure

CAS No. 123-77-3

Purity & Quality Control

Choose Selective Anti-infection Inhibitors

Biological Activity

Description Azodicarbonamide is the first known nucleocapsid inhibitor that inhibits HIV-1 and a broad range of retroviruses by targeting the nucleocapsid CCHC domains. Azodicarbonamide inhibits the HIV-1RF-induced cytopathicity of CEM-SS cells with an EC50 of 38 µM in a standard cell-based antiviral assay .
Targets
nucleocapsid CCHC domains [1] HIV-1 [1]
(Cell-based assay)
38 μM(EC50)

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 116.08
Formula

C2H4N4O2

CAS No. 123-77-3
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05061277 Not yet recruiting Drug: Recifercept Healthy Pfizer October 25 2023 Phase 1
NCT05360368 Not yet recruiting Drug: HLX07 Solid Tumor Shanghai Henlius Biotech March 30 2023 Phase 1
NCT04838301 Not yet recruiting Drug: Allopregnanolone|Other: Placebo Alzheimer Dementia|Late Onset Alzheimer Disease|Neurodegenerative Diseases University of Arizona|National Institute on Aging (NIA)|Syneos Health|ADM Diagnostics Inc.|University of Southern California January 2023 Phase 2
NCT05442996 Not yet recruiting Drug: HLX35|Drug: HLX10 Solid Tumor Adult Shanghai Henlius Biotech January 6 2023 Phase 1
NCT05212922 Not yet recruiting Drug: YH001 + Toripalimab HCC|NSCLC Stage IIIB|NSCLC Stage IV Eucure (Beijing) Biopharma Co. Ltd December 2022 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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