CAS No. 2517-04-6

Batch: Purity:98
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Azetidine-2-carboxylic acid Chemical Structure
Chemical Structure
Check the Azetidine-2-carboxylic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2517-04-6
Molecular Formula

C4H7NO2
Molecular Weight (MW) 101.10
SMILES C1CNC1C(=O)O

Biological Activity

Azetidine-2-carboxylic acid (L-Aze) is a toxic and teratogenic non-protein amino acid that functions as a structural proline analogue. It is misincorporated into nascent proteins in place of proline during protein synthesis, altering the structural integrity of proline-rich proteins such as collagen and keratin. This aberrant incorporation induces protein misfolding and triggers the unfolded protein response, leading to downstream cellular toxicity and dysfunction.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 20 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.