CAS No. 2376146-48-2

Batch: Purity:99.81
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Azenosertib (Zn-C3) Chemical Structure
Chemical Structure
Check the Azenosertib (Zn-C3) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[(7R)-7-ethyl-7-hydroxy-5,6-dihydrocyclopenta[b]pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one
CAS Number 2376146-48-2
Molecular Formula

C29H34N8O2
Molecular Weight (MW) 526.63
SMILES CCC1(O)CCC2=CC=C(N=C12)N3N(CC=C)C(=O)C4=CN=C(NC5=CC=C(C=C5)N6CCN(C)CC6)N=C34
InChIKey OXTSYWDBUVRXFF-GDLZYMKVSA-N

Ordering Information

Biological Activity

Azenosertib (Zn-C3) is an orally active, highly potent, and selective Wee1 kinase inhibitor. By targeting Wee1, a critical kinase involved in cell cycle checkpoint control, azenosertib abrogates the G2/M cell cycle checkpoint, preventing CDK1 phosphorylation. This dysfunction forces cancer cells into premature mitosis with unrepaired DNA damage, inducing replication stress, genomic instability, and apoptotic cell death to inhibit tumor growth. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (189.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.