CAS No. 123524-52-7
| IUPAC Name | 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | |
|---|---|---|
| CAS Number | 123524-52-7 | |
| Molecular Formula |
C33H34N4O6 |
|
| Molecular Weight (MW) | 582.65 | |
| SMILES | CC1=C(C(C(=C(N1)N)C(=O)OC2CN(C2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC(C)C | |
| InChIKey | ZKFQEACEUNWPMT-UHFFFAOYSA-N |
Azelnidipine is a dihydropyridine calcium channel blocker that acts as a potent inhibitor of L-type calcium channels. By inhibiting transmembrane calcium influx into vascular smooth muscle cells, it promotes vasodilation and suppresses intracellular calcium-dependent signaling cascades. These actions lead to reduced vascular resistance, lowered systemic blood pressure, and vascular protective downstream effects in preclinical cardiovascular disease models.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
117 mg/mL
(200.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
| Water | Insoluble |
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- Mix rapidly (pipette/vortex) upon addition.
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- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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