CAS No. 79307-93-0
| CAS Number | 79307-93-0 | |
|---|---|---|
| Molecular Formula |
C22H24ClN3O.HCl |
|
| Molecular Weight (MW) | 418.36 | |
| SMILES | CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl.Cl |
Azelastine HCl is a potent, selective, second-generation histamine H1 receptor antagonist. It exerts its biological activity by blocking histamine H1 receptors and suppressing mediator release from inflammatory cells. Downstream of receptor inhibition, Azelastine HCl stabilizes mast cells and inhibits the production and activation of inflammatory cytokines and leukotrienes, thereby attenuating allergic inflammatory responses and vascular hyperpermeability. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(198.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 83 mg/mL |
| Ethanol | 83 mg/mL |
| Water | 83 mg/mL |
| DMSO |
77 mg/mL
(184.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 64 mg/mL |
| Water | 83 mg/mL |
| Ethanol | 83 mg/mL |
| DMSO |
28 mg/mL
(66.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
83 mg/mL
(198.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 83 mg/mL |
| Ethanol | 83 mg/mL |
| DMSO |
84 mg/mL
(200.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 84 mg/mL |
| Water | 35 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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