CAS No. 2222844-89-3

Batch: Purity:99.38
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Camizestrant (AZD9833) Chemical Structure
Chemical Structure
Check the Camizestrant (AZD9833) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-3,6,8,9-tetrahydropyrazolo[4,5-f]isoquinolin-6-yl]pyridin-3-amine
CAS Number 2222844-89-3
Molecular Formula

C24H28F4N6
Molecular Weight (MW) 476.51
SMILES CC1CC2=C(C=CC3=C2C=N[NH]3)C(N1CC(F)(F)F)C4=NC=C(NC5CN(CCCF)C5)C=C4
InChIKey WDHOIABIERMLGY-CMJOXMDJSA-N

Ordering Information

Biological Activity

Camizestrant (AZD9833) is an orally bioavailable, selective estrogen receptor degrader and antagonist of estrogen receptor alpha (ERα). It binds to ERα to induce targeted receptor degradation, thereby blocking estrogen-mediated transcriptional signaling and downstream gene expression. Through this dual degradative and antagonistic mechanism, camizestrant potently inhibits cellular proliferation in ER-positive breast cancer cell lines and suppresses tumor growth in preclinical xenograft models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 95 mg/mL (199.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 95 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.