CAS No. 1620576-64-8
Batch:
Purity:99.01
Chemical Structure
Check the
AZD8835
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[4-[5-[5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl]-1-ethyl-1,2,4-triazol-3-yl]piperidin-1-yl]-3-hydroxypropan-1-one | |
|---|---|---|
| CAS Number | 1620576-64-8 | |
| Molecular Formula |
C22H31N9O3 |
|
| Molecular Weight (MW) | 469.54 | |
| SMILES | CCN1C(=NC(=N1)C2CCN(CC2)C(=O)CCO)C3=CN=C(C(=N3)C4=NN=C(O4)C(C)(C)C)N | |
| InChIKey | ZGRDYKFVDCFJCZ-UHFFFAOYSA-N |
AZD8835 is a potent and selective dual inhibitor targeting PI3Kα and PI3Kδ with marked selectivity over PI3Kβ and PI3Kγ isoforms. By inhibiting these class I PI3K enzymes, the compound suppresses downstream AKT/mTOR signaling pathway activation. This blockade results in inhibition of cellular proliferation and induction of apoptosis in tumor models harboring PIK3CA mutations. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
93 mg/mL
(198.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.