CAS No. 911715-90-7
Batch:
Purity:95.11
Chemical Structure
Check the
AZD8797( KAND567)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R)-2-[[2-amino-5-[(1S)-1-phenylethyl]sulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol | |
|---|---|---|
| CAS Number | 911715-90-7 | |
| Molecular Formula |
C19H25N5OS2 |
|
| Molecular Weight (MW) | 403.57 | |
| InChIKey | ZMQSLMZOWVGBSM-GXTWGEPZSA-N |
AZD8797 (KAND567) is an orally active, allosteric non-competitive antagonist of the human chemokine receptor CX3CR1. By binding CX3CR1, it interferes with CX3CL1-induced G-protein activation and exhibits biased modulation of G-protein signaling and β-arrestin recruitment. This selective inhibition blocks CX3CL1-mediated leukocyte adhesion in human whole blood (IC50 300 nM) and cell migration, suppressing downstream neuroinflammatory and immune trafficking pathways. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
81 mg/mL
(200.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 81 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.