CAS No. 3047321-53-6
Batch:
Purity:99.26
Chemical Structure
Check the
AZD8421
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3S)-N-ethyl-3-[[9-ethyl-2-[[(2R,3S)-2-hydroxypentan-3-yl]amino]purin-6-yl]amino]pyrrolidine-1-sulfonamide | |
|---|---|---|
| CAS Number | 3047321-53-6 | |
| Molecular Formula |
C18H32N8O3S |
|
| Molecular Weight (MW) | 440.57 | |
| InChIKey | ROGNUCVYDNPNJI-RDBSUJKOSA-N |
AZD8421 is a potent and selective inhibitor of cyclin-dependent kinase 2 (CDK2) with high selectivity over CDK1, CDK4, and CDKInhibition of CDK2 activity leads to reduced retinoblastoma protein phosphorylation, inducing G1/S cell cycle arrest and cellular senescence. These molecular downstream effects disrupt cell cycle progression and inhibit proliferation, exhibiting marked therapeutic activity in breast and ovarian cancer models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 88 mg/mL |
| DMSO |
44 mg/mL
(99.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.