CAS No. 2143010-83-5

Batch: Purity:99.78
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AZD5991 Chemical Structure
Chemical Structure
Check the AZD5991 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(36),4(38),6,11,14,16,18,20,23,29(37),30,32,34-tridecaene-23-carboxylic acid
CAS Number 2143010-83-5
Molecular Formula

C35H34ClN5O3S2
Molecular Weight (MW) 672.26
SMILES CC1=C2C(=NN1C)CSCC3=NN(C(=C3)CSC4=CC5=CC=CC=C5C(=C4)OCCCC6=C(N(C7=C6C=CC(=C27)Cl)C)C(=O)O)C
InChIKey KBQCEQAXHPIRTF-UHFFFAOYSA-N

Ordering Information

Biological Activity

AZD5991 is a macrocyclic MCL-1 inhibitor that binds human MCL-1 with sub-nanomolar affinity (Ki =. It selectively disrupts the interaction between MCL-1 and pro-apoptotic proteins such as BAK, activating the intrinsic apoptotic pathway. This targeted inhibition leads to rapid, caspase-dependent cell death and demonstrates robust preclinical antitumor efficacy in hematological malignancy models, particularly multiple myeloma and acute myeloid leukemia. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 25 mg/mL (37.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.