CAS No. 2489226-14-2
Chemical Structure
Check the
AZD4747
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[(4aR)-8-(2-chloro-6-hydroxyphenyl)-7-fluoro-9-prop-1-ynyl-1,2,4,4a,5,11-hexahydropyrazino[2,1-c][1,4]benzoxazepin-3-yl]prop-2-en-1-one | |
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| CAS Number | 2489226-14-2 | |
| Molecular Formula |
C24H22ClFN2O3 |
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| Molecular Weight (MW) | 440.90 | |
| InChIKey | CNQOLVBNICGIJB-QGZVFWFLSA-N |
AZD4747 is a potent, selective, and blood-brain barrier-permeable inhibitor of mutant GTPase KRASG12C. By binding to mutant KRASG12C, it suppresses oncogenic RAS/MAPK signaling pathways, thereby inhibiting tumor cell growth, survival, and proliferation in KRASG12C-mutant malignancies. Additionally, its blood-brain barrier penetration allows for therapeutic brain exposure, making it capable of targeting central nervous system metastases arising from KRASG12C-driven primary tumors. [1]
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Note: Technical data last updated: Sep 1, 2026.