CAS No. 1035270-39-3

Batch: Purity:99.94
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AZD4547 (Fexagratinib) Chemical Structure
Chemical Structure
Check the AZD4547 (Fexagratinib) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide
CAS Number 1035270-39-3
Molecular Formula

C26H33N5O3
Molecular Weight (MW) 463.57
SMILES CC1CN(CC(N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC
InChIKey VRQMAABPASPXMW-HDICACEKSA-N

Biological Activity

AZD4547 (Fexagratinib) is a selective fibroblast growth factor receptor (FGFR) inhibitor targeting FGFR1, FGFR2, and FGFR3, with weaker activity against FGFR4. It inhibits FGFR autophosphorylation and suppresses downstream signaling through FRS2, PLCγ, and MAPK pathways. This pathway blockade leads to potent antiproliferative effects in FGFR-dependent tumor cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 93 mg/mL (200.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Gavine PR, et al. Cancer Res. 2012;72(8):2045-56.

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Note: Technical data last updated: Sep 1, 2026.