CAS No. 883986-34-3
Batch:
Purity:99.59
Chemical Structure
Check the
AZD2932
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-N-(1-propan-2-ylpyrazol-4-yl)acetamide | |
|---|---|---|
| CAS Number | 883986-34-3 | |
| Molecular Formula |
C24H25N5O4 |
|
| Molecular Weight (MW) | 447.49 | |
| SMILES | CC(C)N1C=C(C=N1)NC(=O)CC2=CC=C(C=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC | |
| InChIKey | TWYCZJMOEMMCGC-UHFFFAOYSA-N |
Biological Activity
AZD2932 is a potent, multi-targeted receptor tyrosine kinase inhibitor targeting VEGFR-2, PDGFRβ, Flt-3, and c-Kit. By blocking these receptor tyrosine kinases, AZD2932 inhibits downstream signaling pathways, including the AKT/mTOR and MAPK/ERK cascades. This inhibition suppresses endothelial cell proliferation, impairs angiogenesis, and disrupts tumor cell growth and survival phenotypes across various experimental models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
89 mg/mL
(198.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.