CAS No. 566203-88-1

Batch: Purity:99.39
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AZD2098 Chemical Structure
Chemical Structure
Check the AZD2098 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2,3-dichloro-N-(3-methoxypyrazin-2-yl)benzenesulfonamide
CAS Number 566203-88-1
Molecular Formula

C11H9Cl2N3O3S
Molecular Weight (MW) 334.18
SMILES COC1=NC=CN=C1NS(=O)(=O)C2=C(C(=CC=C2)Cl)Cl
InChIKey FLSMVCMSUNISFK-UHFFFAOYSA-N

Biological Activity

AZD2098 is a potent CC chemokine receptor 4 (CCR4) antagonist that targets CCR4-mediated signaling pathways. By blocking CCR4 functional interactions with its key chemokine ligands, it effectively suppresses downstream leukocyte chemotaxis, cellular signaling, and lymphocyte migration, thereby modulating inflammatory phenotypes and immune cell responses driven by T helper 2 and regulatory T cell populations. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 67 mg/mL (200.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 4 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Yoshie O, et al. Int Immunol. 2015;27(1):11-20.

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Note: Technical data last updated: Sep 1, 2026.