CAS No. 2089288-03-7
| IUPAC Name | 7-fluoro-3-methyl-8-[6-(3-piperidin-1-ylpropoxy)-3-pyridinyl]-1-propan-2-ylimidazo[4,5-c]quinolin-2-one | |
|---|---|---|
| CAS Number | 2089288-03-7 | |
| Molecular Formula |
C27H32FN5O2 |
|
| Molecular Weight (MW) | 477.57 | |
| SMILES | CC(C)N1C2=C(C=NC3=CC(=C(C=C32)C4=CN=C(C=C4)OCCCN5CCCCC5)F)N(C1=O)C | |
| InChIKey | VQSZIPCGAGVRRP-UHFFFAOYSA-N |
AZD1390 is an orally active, central nervous system-penetrant ataxia telangiectasia mutated kinase inhibitor displaying a cellular IC50 of 0.78 nM and >10,000-fold selectivity over other PIKK family members. By selectively blocking ATM signaling, it impairs double-strand break repair while suppressing the radiation-induced DNA damage response. Consequently, AZD1390 radiosensitizes tumor cells and promotes radiation-induced cell death in preclinical models. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 95 mg/mL |
| DMSO |
14 mg/mL
(29.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | 95 mg/mL |
| DMSO |
14 mg/mL
(29.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | 24 mg/mL |
| DMSO |
16 mg/mL
(33.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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