CAS No. 2455427-91-3
Batch:
Purity:95.01
Chemical Structure
Check the
AZD0780
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1-[6-[[(1S,3S)-3-[[5-(difluoromethoxy)pyrimidin-2-yl]amino]cyclopentyl]amino]-3-pyridinyl]pyridin-2-one | |
|---|---|---|
| CAS Number | 2455427-91-3 | |
| Molecular Formula |
C20H20F2N6O2 |
|
| Molecular Weight (MW) | 414.41 | |
| InChIKey | NCHUWRLOTSAFFN-KBPBESRZSA-N |
Biological Activity
AZD0780 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor that directly binds to PCSK9 to block its interaction with target receptors. By inhibiting PCSK9 function, AZD0780 prevents PCSK9-mediated low-density lipoprotein receptor (LDLR) degradation, resulting in increased cell-surface LDLR levels and enhanced clearance of circulating LDL cholesterol, making it useful for dyslipidemia research. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(200.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.