CAS No. 2750001-23-9

Batch: Purity:99.72
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AZD0095 Chemical Structure
Chemical Structure
Check the AZD0095 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[[6-[4-[(3R)-3-[(2,5,7-trimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)oxy]pyrrolidin-1-yl]phenyl]pyridazin-3-yl]methyl]morpholine
CAS Number 2750001-23-9
Molecular Formula

C27H32N8O2
Molecular Weight (MW) 500.60
InChIKey PHDAGSZQGNWGFE-XMMPIXPASA-N

Ordering Information

Biological Activity

AZD0095 is an orally active, selective monocarboxylate transporter 4 (MCT4) inhibitor 3 nM) with >1000-fold selectivity over MCT1. By blocking MCT4-mediated cellular lactic acid export under hypoxic conditions, AZD0095 impairs intracellular lactate homeostasis and reverses lactate-driven immunosuppression in the tumor microenvironment. Consequently, MCT4 inhibition disrupts glycolytic metabolism and effectively inhibits tumor growth in combination with cediranib. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 13 mg/mL (25.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.