CAS No. 2958627-18-2
Batch:
Purity:99.30
Chemical Structure
Check the
AZD0022
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[4-(3,8-diazabicyclo[3.2.1]oct-6-en-3-yl)-6,8-difluoro-2-[(2-fluoro-1,2,3,5,6,7-hexahydropyrrolizin-8-yl)methoxy]quinazolin-7-yl]-5-ethynyl-6-fluoronaphthalen-2-amine | |
|---|---|---|
| CAS Number | 2958627-18-2 | |
| Molecular Formula |
C34H30F4N6O |
|
| Molecular Weight (MW) | 614.64 | |
| InChIKey | HLFQZDAHMCQMND-UHFFFAOYSA-N |
AZD0022 is a potent, orally bioavailable, selective, and reversible small-molecule inhibitor targeting the KRAS G12D mutant protein. By directly engaging KRAS G12D, it disrupts downstream RAS pathway signaling, including the MAPK and AKT kinase cascades. This robust pathway inhibition suppresses cell proliferation and survival, ultimately driving marked anti-tumor activity across KRAS G12D-mutated cancer models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(162.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.