CAS No. 2787501-83-9
Batch:
Purity:99.03
Chemical Structure
Check the
AZD-5462
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[2-fluoro-4-methoxy-5-[[(1S,2R,3S,4R)-3-[(1-methylcyclobutyl)methylcarbamoyl]-2-bicyclo[2.2.1]heptanyl]carbamoyl]phenoxy]-1-methylcyclohexane-1-carboxylic acid | |
|---|---|---|
| CAS Number | 2787501-83-9 | |
| Molecular Formula |
C30H41FN2O6 |
|
| Molecular Weight (MW) | 544.66 | |
| InChIKey | LYUYYIGCZIZIGF-SRHODNEWSA-N |
Biological Activity
AZD-5462 is a selective oral allosteric agonist of relaxin family peptide receptor 1 (RXFP1), belonging to G-protein coupled receptor family 1c. Engagement of RXFP1 activates downstream cAMP signaling pathways in a manner similar to endogenous human relaxin-This target activation leads to prominent anti-fibrotic and anti-inflammatory cellular phenotypes, promoting cardiac functional preservation in models of heart failure. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(183.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.